NADH Dehydrogenase Electron Carriers

Dehydrogenase is an enzyme that oxidizes a substrate by transferring one or more protons and a pair of electrons to an acceptor, usually NAD/NADP or a flavin coenzyme such as FAD or FMN. Most necessarily contain a rossman fold to bind the dinucleotide on one domain, with the substrate-binding region on another domain. Essentially, this is modular design of a protein with the two functions (cofactor binding and substrate binding) as separate evolutionary units. Since DHs are essential to most metabolic pathways including glycolysis and the TCA cycle, it is possible that they are quite ancient proteins.

Common examples of dehydrogenase enzymes in the TCA cycle are isocitrate dehydrogenase, alcohol dehydrogenase, acetaldehyde dehydrogenase and alpha-ketoglutarate dehydrogenase. Pyruvate dehydrogenase, another common dehydrogenase enzyme, feeds the TCA Cycle in converting Pyruvate to Acetyl CoA.

Our database on Dehydrogenase is in a well organized format of a large collection of dehydrogenase enzymes (more than 500) from different species. It is an hierarchical, structured based classification of all the enzyme dehydrogenase. Overlay this database contains brief literature information about the Summary, Sequences, Taxonomic characteristics, Phyllogenetic analysis, Structures, Some Special Features, References and links to other Resources. This is completely web based.